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The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
Gaster LM, Ham P, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Price GW, Roberts C, Routledge C, Selkirk J, Slade PD, Middlemiss DN. Gaster LM, et al. Among authors: middlemiss dn. Ann N Y Acad Sci. 1998 Dec 15;861:270-1. doi: 10.1111/j.1749-6632.1998.tb10219.x. Ann N Y Acad Sci. 1998. PMID: 9928285 No abstract available.
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Hatcher J, Jones BJ, Middlemiss DN, Price GW, Riley G, Roberts C, Routledge C, Selkirk J, Slade PD. Gaster LM, et al. Among authors: middlemiss dn. J Med Chem. 1998 Apr 9;41(8):1218-35. doi: 10.1021/jm970457s. J Med Chem. 1998. PMID: 9548813
SB-236057-A: a selective 5-HT1B receptor inverse agonist.
Roberts C, Watson J, Price GW, Middlemiss DN. Roberts C, et al. Among authors: middlemiss dn. CNS Drug Rev. 2001 Winter;7(4):433-44. doi: 10.1111/j.1527-3458.2001.tb00209.x. CNS Drug Rev. 2001. PMID: 11830759 Free PMC article. Review.
Species differences in 5-HT autoreceptors.
Price GW, Roberts C, Watson J, Burton M, Mulholland K, Middlemiss DN, Jones BJ. Price GW, et al. Among authors: middlemiss dn. Behav Brain Res. 1996;73(1-2):79-82. doi: 10.1016/0166-4328(96)00074-5. Behav Brain Res. 1996. PMID: 8788481
139 results