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248 results

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Page 1
Stapled Phd Peptides Inhibit Doc Toxin Induced Growth Arrest in Salmonella.
Worm DJ, Grabe GJ, de Castro GV, Rabinovich S, Warm I, Isherwood K, Helaine S, Barnard A. Worm DJ, et al. ACS Chem Biol. 2023 Dec 15;18(12):2485-2494. doi: 10.1021/acschembio.3c00411. Epub 2023 Nov 21. ACS Chem Biol. 2023. PMID: 38098459 Free PMC article.
Bacterial toxin inhibition is a promising approach to overcoming antibiotic failure. InSalmonella, knockout of the toxin Doc has been shown to significantly reduce the formation of antibiotic-tolerant persisters. Doc is a kinase that is inhibited in no …
Bacterial toxin inhibition is a promising approach to overcoming antibiotic failure. InSalmonella, knockout of the toxin Do …
Doc toxin is a kinase that inactivates elongation factor Tu.
Cruz JW, Rothenbacher FP, Maehigashi T, Lane WS, Dunham CM, Woychik NA. Cruz JW, et al. J Biol Chem. 2014 Mar 14;289(11):7788-98. doi: 10.1074/jbc.M113.544429. Epub 2014 Jan 21. J Biol Chem. 2014. PMID: 24448800 Free PMC article.
The Doc toxin from bacteriophage P1 (of the phd-doc toxin-antitoxin system) has served as a model for the family of Doc toxins, many of which are harbored in the genomes of pathogens. ...This distinct enzymatic activity exhibited by P1 …
The Doc toxin from bacteriophage P1 (of the phd-doc toxin-antitoxin system) has served as a model for the family …
Characterization of the Key Determinants of Phd Antitoxin Mediated Doc Toxin Inactivation in Salmonella.
de Castro GV, Worm DJ, Grabe GJ, Rowan FC, Haggerty L, de la Lastra AL, Popescu O, Helaine S, Barnard A. de Castro GV, et al. ACS Chem Biol. 2022 Jun 17;17(6):1598-1606. doi: 10.1021/acschembio.2c00276. Epub 2022 Jun 1. ACS Chem Biol. 2022. PMID: 35647667 Free PMC article.
The bacterial toxin Doc has been associated with the persistence of Salmonella in macrophages, enabling its survival upon antibiotic exposure. ...Coexpression of Doc and antitoxin peptides in Salmonella was able to counteract the activity of the toxin, …
The bacterial toxin Doc has been associated with the persistence of Salmonella in macrophages, enabling its survival upon anti …
Expanded hemodialysis: what's up, Doc?
García-Prieto A, de la Flor JC, Coll E, Iglesias E, Reque J, Valga F. García-Prieto A, et al. Clin Kidney J. 2023 Feb 20;16(7):1071-1080. doi: 10.1093/ckj/sfad033. eCollection 2023 Jul. Clin Kidney J. 2023. PMID: 37398691 Free PMC article. Review.
Type II bacterial toxin-antitoxins: hypotheses, facts, and the newfound plethora of the PezAT system.
Chan WT, Garcillán-Barcia MP, Yeo CC, Espinosa M. Chan WT, et al. FEMS Microbiol Rev. 2023 Sep 5;47(5):fuad052. doi: 10.1093/femsre/fuad052. FEMS Microbiol Rev. 2023. PMID: 37715317 Free PMC article.
Toxin-antitoxin (TA) systems are entities found in the prokaryotic genomes, with eight reported types. ...PezT/Zeta toxins phosphorylate the peptidoglycan precursors, thereby blocking cell wall synthesis. ...
Toxin-antitoxin (TA) systems are entities found in the prokaryotic genomes, with eight reported types. ...PezT/Zeta toxins pho …
Crystallization of Doc and the Phd-Doc toxin-antitoxin complex.
Garcia-Pino A, Dao-Thi MH, Gazit E, Magnuson RD, Wyns L, Loris R. Garcia-Pino A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1034-8. doi: 10.1107/S1744309108031722. Epub 2008 Oct 28. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18997335 Free PMC article.
The phd/doc addiction system is responsible for the stable inheritance of lysogenic bacteriophage P1 in its plasmidic form in Escherichia coli and is the archetype of a family of bacterial toxin-antitoxin modules. The His66Tyr mutant of Doc (Doc(H66Y)) …
The phd/doc addiction system is responsible for the stable inheritance of lysogenic bacteriophage P1 in its plasmidic form in Escheri …
Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit.
Liu M, Zhang Y, Inouye M, Woychik NA. Liu M, et al. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5885-90. doi: 10.1073/pnas.0711949105. Epub 2008 Apr 8. Proc Natl Acad Sci U S A. 2008. PMID: 18398006 Free PMC article.
To date, the mechanism of action of the majority of known TA toxins has not yet been elucidated. We determined the mode of action of the Doc toxin of the Phd-Doc TA system. ...However, Doc did not cleave mRNA as do other addiction-module toxi …
To date, the mechanism of action of the majority of known TA toxins has not yet been elucidated. We determined the mode of action of …
Who Needs Reference Materials?
Phillips M, Emteborg H. Phillips M, et al. J AOAC Int. 2016 Sep;99(5):1145. doi: 10.5740/jaoacint.16-0188. J AOAC Int. 2016. PMID: 27619654 Free PMC article. No abstract available.
248 results