HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis.
Czopik AK, McNamee EN, Vaughn V, Huang X, Bang IH, Clark T, Wang Y, Ruan W, Nguyen T, Masterson JC, Tak E, Frank S, Collins CB, Li H, Rodriguez-Aguayo C, Lopez-Berestein G, Gerich ME, Furuta GT, Yuan X, Sood AK, de Zoeten EF, Eltzschig HK.
Czopik AK, et al.
Nat Commun. 2024 Sep 14;15(1):8042. doi: 10.1038/s41467-024-52113-y.
Nat Commun. 2024.
PMID: 39271652
Free PMC article.
Our assays reveal markedly increased T cell-intrinsic hypoxia and stabilization of HIF protein during experimental colitis. microRNA screen in primary CD4(+) T cells points us towards miR-29a and our subsequent studies identify a selective role for HIF-2alpha in CD4-cell-i …
Our assays reveal markedly increased T cell-intrinsic hypoxia and stabilization of HIF protein during experimental colitis. microRNA screen …