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The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
Schwecke T, Aparicio JF, Molnár I, König A, Khaw LE, Haydock SF, Oliynyk M, Caffrey P, Cortés J, Lester JB, et al. Schwecke T, et al. Among authors: khaw le. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7839-43. doi: 10.1073/pnas.92.17.7839. Proc Natl Acad Sci U S A. 1995. PMID: 7644502 Free PMC article.
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). ...
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific bind …