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Year Number of Results
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1922 6
1923 3
1924 1
1925 3
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1927 3
1928 6
1929 1
1930 1
1932 1
1933 2
1934 1
1935 1
1936 2
1937 1
1938 5
1939 2
1940 4
1941 3
1942 2
1943 1
1944 4
1945 7
1946 23
1947 27
1948 44
1949 48
1950 37
1951 46
1952 45
1953 62
1954 60
1955 38
1956 62
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1958 75
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1968 571
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1972 945
1973 1119
1974 1238
1975 1796
1976 1822
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1978 1813
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1980 2133
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1982 2614
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1997 11060
1998 12142
1999 12675
2000 13750
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2002 14321
2003 14896
2004 15789
2005 16353
2006 17205
2007 18063
2008 18354
2009 18202
2010 18925
2011 19616
2012 19501
2013 19853
2014 19367
2015 19232
2016 18328
2017 17897
2018 17619
2019 17802
2020 18458
2021 19137
2022 18464
2023 16991
2024 16689
2025 249

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537,959 results

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Page 1
A glossy mutant in onion (Allium cepa L.) shows decreased expression of wax biosynthesis genes.
Manape TK, Soumia PS, Khade YP, Satheesh V, Anandhan S. Manape TK, et al. Front Plant Sci. 2023 Aug 23;14:1245308. doi: 10.3389/fpls.2023.1245308. eCollection 2023. Front Plant Sci. 2023. PMID: 37680361 Free PMC article.
The inheritance of the mutant's glossy phenotype was determined to be recessive and single locus. Scanning electron microscopy analysis showed poor accumulation of wax crystals in the glossy mutant, concentrated near the stomata. The plant height, number of l …
The inheritance of the mutant's glossy phenotype was determined to be recessive and single locus. Scanning electron microscopy …
Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease.
Buglo E, Sarmiento E, Martuscelli NB, Sant DW, Danzi MC, Abrams AJ, Dallman JE, Züchner S. Buglo E, et al. PLoS One. 2020 Mar 24;15(3):e0230566. doi: 10.1371/journal.pone.0230566. eCollection 2020. PLoS One. 2020. PMID: 32208444 Free PMC article.
We report a case of genetic compensation in a stable slc25a46 homozygous zebrafish mutant (hereafter referred as "mutant"), in contrast to a penetrant disease phenotype in the first generation (F0) slc25a46 mosaic mutant (hereafter referred as "crispant"), ge …
We report a case of genetic compensation in a stable slc25a46 homozygous zebrafish mutant (hereafter referred as "mutant"), in …
Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms.
van Opijnen T, Bodi KL, Camilli A. van Opijnen T, et al. Nat Methods. 2009 Oct;6(10):767-72. doi: 10.1038/nmeth.1377. Epub 2009 Sep 20. Nat Methods. 2009. PMID: 19767758 Free PMC article.
After library selection, changes in frequency of each insertion mutant are determined by sequencing the flanking regions en masse. These changes are used to calculate each mutant's fitness. ...
After library selection, changes in frequency of each insertion mutant are determined by sequencing the flanking regions en masse. Th …
The Arabidopsis T-DNA mutant SALK_008491 carries a 14-kb deletion on chromosome 3 that provides rare insights into the plant response to dynamic light stress.
Lopez LS, Völkner C, Day PM, Lewis CM, Lewis CL, Schneider D, Correa Galvis V, Cruz JA, Armbruster U, Kramer DM, Kunz HH. Lopez LS, et al. Plant Direct. 2022 Jul 20;6(7):e429. doi: 10.1002/pld3.429. eCollection 2022 Jul. Plant Direct. 2022. PMID: 35875836 Free PMC article.
Although some changes in the SALK_008491 mutant's photosynthesis can be assigned to the loss of PGDH3, our follow-up studies employing respective single mutants and complementation with overlapping transformation-competent artificial chromosome (TAC) vectors …
Although some changes in the SALK_008491 mutant's photosynthesis can be assigned to the loss of PGDH3, our follow-up studies e …
PEGylation of a glycosaminoglycan-binding, dominant-negative CXCL8 mutant retains bioactivity in vitro and in vivo.
Gerlza T, Trojacher C, Jeremic D, Krieger E, Adage T, Kungl A. Gerlza T, et al. Cytokine. 2020 Mar;127:154942. doi: 10.1016/j.cyto.2019.154942. Epub 2019 Nov 30. Cytokine. 2020. PMID: 31794956
We have recently shown that a dominant-negative mutant of CXCL8, dnCXCL8, with increased glycosaminoglycan (GAG) binding affinity and inactivated GPCR signaling function is able to efficiently prevent neutrophil infiltration into murine lungs (Adage et al., 2015). Here we …
We have recently shown that a dominant-negative mutant of CXCL8, dnCXCL8, with increased glycosaminoglycan (GAG) binding affinity and …
Vitamin C and Vitamin D3 show strong binding with the amyloidogenic region of G555F mutant of Fibrinogen A alpha-chain associated with renal amyloidosis: proposed possible therapeutic intervention.
Pande M, Kundu D, Srivastava R. Pande M, et al. Mol Divers. 2022 Apr;26(2):939-949. doi: 10.1007/s11030-021-10205-7. Epub 2021 Mar 12. Mol Divers. 2022. PMID: 33710477
G555F mutant of Fibrinogen A alpha-chain (FGA) is reported to be associated with kidney amyloidosis. In the current study, we have modelled the G555F mutant and examined the mutation's effect on the structural and functional level. We have also docked Vitamin C and …
G555F mutant of Fibrinogen A alpha-chain (FGA) is reported to be associated with kidney amyloidosis. In the current study, we have mo …
A Listeria monocytogenes mutant defective in bacteriophage attachment is attenuated in orally inoculated mice and impaired in enterocyte intracellular growth.
Spears PA, Suyemoto MM, Palermo AM, Horton JR, Hamrick TS, Havell EA, Orndorff PE. Spears PA, et al. Infect Immun. 2008 Sep;76(9):4046-54. doi: 10.1128/IAI.00283-08. Epub 2008 Jun 16. Infect Immun. 2008. PMID: 18559424 Free PMC article.
Interestingly, the glcV lesion, while preventing phage attachment, did not alter the mutant's ability to bind to cultured mouse enterocyte monolayers. Rather, the mutation appeared to alter a subsequent step in intracellular replication measured by a reduction in pl …
Interestingly, the glcV lesion, while preventing phage attachment, did not alter the mutant's ability to bind to cultured mous …
Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin.
Kume K, Koyano T, Takata J, Wakabayashi K, Mizunuma M, Miyakawa T, Hirata D. Kume K, et al. Biosci Biotechnol Biochem. 2015;79(5):790-4. doi: 10.1080/09168451.2014.1003132. Epub 2015 Jan 23. Biosci Biotechnol Biochem. 2015. PMID: 25614218
Calcineurin, which is a Ca(2+)/calmodulin-dependent protein phosphatase, is a key mediator in calcium signaling in diverse biological processes and of clinical importance as the target of the immunosuppressant FK506. To identify a mutant(s) in which calcineurin is a …
Calcineurin, which is a Ca(2+)/calmodulin-dependent protein phosphatase, is a key mediator in calcium signaling in diverse biological proces …
An experimental protocol for teaching CRISPR/Cas9 in a post-graduate plant laboratory course: An analysis of mutant-edited plants without sequencing.
Mayta ML, Dotto M, Orellano EG, Krapp AR. Mayta ML, et al. Biochem Mol Biol Educ. 2022 Sep;50(5):537-546. doi: 10.1002/bmb.21659. Epub 2022 Jul 27. Biochem Mol Biol Educ. 2022. PMID: 35894125 Free article.
To teach its principles to post-graduate students we designed a laboratory activity to obtain and analyze PDS3 mutants in Arabidopsis thaliana plants consisting of: 1) Design of guide RNAs using bioinformatics tools; 2) plant transformation (which is optional depending on …
To teach its principles to post-graduate students we designed a laboratory activity to obtain and analyze PDS3 mutants in Arabidopsis …
Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis.
Álvarez-Álvarez R, Rodríguez-García A, Martínez-Burgo Y, Martín JF, Liras P. Álvarez-Álvarez R, et al. Appl Environ Microbiol. 2018 Oct 30;84(22):e01701-18. doi: 10.1128/AEM.01701-18. Print 2018 Nov 15. Appl Environ Microbiol. 2018. PMID: 30194098 Free PMC article.
A transcriptomic study of the oppA2-null mutant S. clavuligerus deltaoppA2::aac showed changes in the expression levels of 233 genes from those in the parental strain. ...The oppA2-mutant is known to release N-acetylglycyl-clavaminic acid to the broth. Cosynt …
A transcriptomic study of the oppA2-null mutant S. clavuligerus deltaoppA2::aac showed changes in the expression levels of 233 …
537,959 results
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