Intranasal administration of budesonide-loaded nanocapsule microagglomerates as an innovative strategy for asthma treatment.
Ortiz M, de Sa Coutinho D, Ciambarella BT, de Souza ET, D'Almeida APL, Durli TL, Rodrigues E Silva PM, Bernardi A, Sonvico F, Pohlmann AR, Martins MA, Guterres SS.
Ortiz M, et al.
Drug Deliv Transl Res. 2020 Dec;10(6):1700-1715. doi: 10.1007/s13346-020-00813-5.
Drug Deliv Transl Res. 2020.
PMID: 32789546
The powder showed a bimodal size distribution curve by laser diffraction with a principal peak just above 3 mum and a second one around 0.45 mum and a drug content determined by HPLC of 8.7 mg of budesonide per gram. In vivo after nasal administration, BudNC showed an impr …
The powder showed a bimodal size distribution curve by laser diffraction with a principal peak just above 3 mum and a second one around 0.45 …