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Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.
Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. Sinha M, et al. Science. 2014 May 9;344(6184):649-52. doi: 10.1126/science.1251152. Epub 2014 May 5. Science. 2014. PMID: 24797481 Free PMC article.
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy.
Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Loffredo FS, et al. Cell. 2013 May 9;153(4):828-39. doi: 10.1016/j.cell.2013.04.015. Cell. 2013. PMID: 23663781 Free PMC article.