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Decreased Penetrance of Parkinson's Disease in Elderly Carriers of Glucocerebrosidase Gene L444P/R Mutations: A Community-Based 10-Year Longitudinal Study.
Ji S, Wang C, Qiao H, Gu Z, Gan-Or Z, Fon EA, Chan P. Ji S, et al. Mov Disord. 2020 Apr;35(4):672-678. doi: 10.1002/mds.27971. Epub 2020 Jan 8. Mov Disord. 2020. PMID: 31912918
OBJECTIVES: To assess the conversion rate to PD in identified carriers of GBA L444P/R mutations in Chinese community-dwelling older adults. METHODS: The GBA gene was sequenced for mutations at position 444 in 8405 people older than 55 years who participated in the Beijing …
OBJECTIVES: To assess the conversion rate to PD in identified carriers of GBA L444P/R mutations in Chinese community-dwelling older a …
Lysophospholipids and branched chain amino acids are associated with aging: a metabolomics-based study of Chinese adults.
Pan Y, Liu P, Li S, Li B, Li Y, Ma L. Pan Y, et al. Eur J Med Res. 2023 Feb 2;28(1):58. doi: 10.1186/s40001-023-01021-w. Eur J Med Res. 2023. PMID: 36732870 Free PMC article.
Valine, leucine and isoleucine degradation and biosynthesis were important pathways in aging, with reduced levels of L-isoleucine (r = - 0.30, p = 0.017) and L-leucine (r = - 0.32, p = 0.010) observed in older adults. ...
Valine, leucine and isoleucine degradation and biosynthesis were important pathways in aging, with reduced levels of L-isoleucine (r …