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Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expression.
Cai K, Wang F, Shi HQ, Shen AN, Zhao R, Geng HR, Lu JQ, Gui YH, Shi Y, Zhao JY. Cai K, et al. Cardiovasc Res. 2024 Dec 14;120(16):2092-2103. doi: 10.1093/cvr/cvae203. Cardiovasc Res. 2024. PMID: 39253986
The combined proteomic, RNA expression, and DNA methylation analyses suggested that key genes involved in cardiac function were inhibited at the transcriptional level possibly due to increased DNA methylation. ...
The combined proteomic, RNA expression, and DNA methylation analyses suggested that key genes involved in cardiac function were inhib …
Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer.
Zhang R, Hu M, Liu Y, Li W, Xu Z, He S, Lu Y, Gong Y, Wang X, Hai S, Li S, Qi S, Li Y, Shu Y, Du D, Zhang H, Xu H, Zhou Z, Lei P, Chen HN, Dai L. Zhang R, et al. Genomics Proteomics Bioinformatics. 2024 Oct 15;22(4):qzae053. doi: 10.1093/gpbjnl/qzae053. Genomics Proteomics Bioinformatics. 2024. PMID: 39052867 Free PMC article.
Genomic analysis identified 160 genes with higher mutation frequencies in Low-Mg tumors, including key driver genes such as KMT2C and ERBB3. Unexpectedly, initiation driver genes of CRC, such as TP53 and APC, displayed higher mutation frequencies in High-Mg tumors. ...
Genomic analysis identified 160 genes with higher mutation frequencies in Low-Mg tumors, including key driver genes such as KMT2C and …