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BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo.
Yang Q, To KKW, Hu G, Fu K, Yang C, Zhu S, Pan C, Wang F, Luo K, Fu L. Yang Q, et al. Cell Commun Signal. 2024 Jun 13;22(1):325. doi: 10.1186/s12964-024-01698-4. Cell Commun Signal. 2024. PMID: 38872211 Free PMC article.
P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will investigate the effect of BI-2865, a pan-KRAS inhibitor, on reversing MDR induced by P-gp, BCRP and MRP1 in vitro and in vivo, and i …
P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, …
3D Biofabrication of Microporous Hydrogels for Tissue Engineering.
Liu Z, Wu J, Luo Z, Hou Y, Xuan L, Xiao C, Chang J, Zhang D, Zheng G, Guo J, Tang G, Yu X. Liu Z, et al. Adv Healthc Mater. 2024 Dec 6:e2403583. doi: 10.1002/adhm.202403583. Online ahead of print. Adv Healthc Mater. 2024. PMID: 39641221 Review.