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ZSH-2208: A novel retinoid with potent anti-tumour effects on ESCC stem cells via RARγ-TNFAIP3 axis.
Chen R, Huang X, Hou J, Ni J, Zhao W, Li Q, Jiao H, Cao X. Chen R, et al. Clin Transl Med. 2025 Jan;15(1):e70148. doi: 10.1002/ctm2.70148. Clin Transl Med. 2025. PMID: 39724264 Free PMC article.
Mechanistic exploration revealed that ZSH-2208 inhibits the growth of ESCC-TRCs through modulation of the RARgamma-TNFAIP3 axis. The clinical significance of the key molecule TNFAIP3 in ESCC has also been demonstrated. RESULTS: This study introduces ZSH-2208, a novel retin …
Mechanistic exploration revealed that ZSH-2208 inhibits the growth of ESCC-TRCs through modulation of the RARgamma-TNFAIP3 axis. The clinica …