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A synthetic peptide mimic kills Candida albicans and synergistically prevents infection.
Schaefer S, Vij R, Sprague JL, Austermeier S, Dinh H, Judzewitsch PR, Müller-Loennies S, Lopes Silva T, Seemann E, Qualmann B, Hertweck C, Scherlach K, Gutsmann T, Cain AK, Corrigan N, Gresnigt MS, Boyer C, Lenardon MD, Brunke S. Schaefer S, et al. Nat Commun. 2024 Aug 9;15(1):6818. doi: 10.1038/s41467-024-50491-x. Nat Commun. 2024. PMID: 39122699 Free PMC article.
Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences.
Müller R, König A, Groth S, Zarnowski R, Visser C, Handrianz T, Maufrais C, Krüger T, Himmel M, Lee S, Priest EL, Yildirim D, Richardson JP, Blango MG, Bougnoux ME, Kniemeyer O, d'Enfert C, Brakhage AA, Andes DR, Trümper V, Nehls C, Kasper L, Mogavero S, Gutsmann T, Naglik JR, Allert S, Hube B. Müller R, et al. Nat Microbiol. 2024 Mar;9(3):669-683. doi: 10.1038/s41564-024-01606-z. Epub 2024 Feb 22. Nat Microbiol. 2024. PMID: 38388771