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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
J Cell Biol. 2009 Dec 28;187(7):1083-99. doi: 10.1083/jcb.200909067. Epub 2009 Dec 21.
J Cell Biol. 2009.
PMID: 20026656
Free PMC article.
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW.
Gu X, et al.
Neuron. 2009 Dec 24;64(6):828-40. doi: 10.1016/j.neuron.2009.11.020.
Neuron. 2009.
PMID: 20064390
Free PMC article.
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Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy.
Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE.
Montie HL, et al.
Hum Mol Genet. 2009 Jun 1;18(11):1937-50. doi: 10.1093/hmg/ddp115. Epub 2009 Mar 11.
Hum Mol Genet. 2009.
PMID: 19279159
Free PMC article.
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