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Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction.
Mol Metab. 2022 May;59:101463. doi: 10.1016/j.molmet.2022.101463. Epub 2022 Feb 17.
Mol Metab. 2022.
PMID: 35183795
Free PMC article.
Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development.
Lambrot R, Chan D, Shao X, Aarabi M, Kwan T, Bourque G, Moskovtsev S, Librach C, Trasler J, Dumeaux V, Kimmins S.
Lambrot R, et al.
Cell Rep. 2021 Jul 20;36(3):109418. doi: 10.1016/j.celrep.2021.109418.
Cell Rep. 2021.
PMID: 34289352
Free article.
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Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance.
Lismer A, Siklenka K, Lafleur C, Dumeaux V, Kimmins S.
Lismer A, et al.
Nucleic Acids Res. 2020 Nov 18;48(20):11380-11393. doi: 10.1093/nar/gkaa712.
Nucleic Acids Res. 2020.
PMID: 33068438
Free PMC article.
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