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7TM proteins are not necessarily GPCRs.
Vasiliauskaité-Brooks I, Healey RD, Granier S. Vasiliauskaité-Brooks I, et al. Mol Cell Endocrinol. 2019 Jul 1;491:110397. doi: 10.1016/j.mce.2019.02.009. Epub 2019 Apr 24. Mol Cell Endocrinol. 2019. PMID: 31026477 Review.
Structural insights into adiponectin receptors suggest ceramidase activity.
Vasiliauskaité-Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S. Vasiliauskaité-Brooks I, et al. Nature. 2017 Apr 6;544(7648):120-123. doi: 10.1038/nature21714. Epub 2017 Mar 22. Nature. 2017. PMID: 28329765 Free PMC article.
Discovery and Mechanism of Action of Small Molecule Inhibitors of Ceramidases.
Healey RD, Saied EM, Cong X, Karsai G, Gabellier L, Saint-Paul J, Del Nero E, Jeannot S, Drapeau M, Fontanel S, Maurel D, Basu S, Leyrat C, Golebiowski J, Bossis G, Bechara C, Hornemann T, Arenz C, Granier S. Healey RD, et al. Angew Chem Int Ed Engl. 2022 Jan 10;61(2):e202109967. doi: 10.1002/anie.202109967. Epub 2021 Nov 25. Angew Chem Int Ed Engl. 2022. PMID: 34668624