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Page 1
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Mai TT, Hamaï A, Hienzsch A, Cañeque T, Müller S, Wicinski J, Cabaud O, Leroy C, David A, Acevedo V, Ryo A, Ginestier C, Birnbaum D, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R. Mai TT, et al. Nat Chem. 2017 Oct;9(10):1025-1033. doi: 10.1038/nchem.2778. Epub 2017 May 16. Nat Chem. 2017. PMID: 28937680 Free PMC article.
CD44 regulates epigenetic plasticity by mediating iron endocytosis.
Müller S, Sindikubwabo F, Cañeque T, Lafon A, Versini A, Lombard B, Loew D, Wu TD, Ginestier C, Charafe-Jauffret E, Durand A, Vallot C, Baulande S, Servant N, Rodriguez R. Müller S, et al. Nat Chem. 2020 Oct;12(10):929-938. doi: 10.1038/s41557-020-0513-5. Epub 2020 Aug 3. Nat Chem. 2020. PMID: 32747755 Free PMC article.
Small Molecule Inhibitors of Interferon-Induced JAK-STAT Signalling.
Thoidingjam LK, Blouin CM, Gaillet C, Brion A, Solier S, Niyomchon S, El Marjou A, Mouasni S, Sepulveda FE, de Saint Basile G, Lamaze C, Rodriguez R. Thoidingjam LK, et al. Angew Chem Int Ed Engl. 2022 Aug 8;61(32):e202205231. doi: 10.1002/anie.202205231. Epub 2022 Jun 14. Angew Chem Int Ed Engl. 2022. PMID: 35612562 Free PMC article.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Goncalves J, Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J. Goncalves J, et al. Cancer Res. 2021 Jul 1;81(13):3480-3494. doi: 10.1158/0008-5472.CAN-20-2936. Epub 2021 Jun 14. Cancer Res. 2021. PMID: 34127497 Free PMC article.
Click chemistry enables preclinical evaluation of targeted epigenetic therapies.
Tyler DS, Vappiani J, Cañeque T, Lam EYN, Ward A, Gilan O, Chan YC, Hienzsch A, Rutkowska A, Werner T, Wagner AJ, Lugo D, Gregory R, Ramirez Molina C, Garton N, Wellaway CR, Jackson S, MacPherson L, Figueiredo M, Stolzenburg S, Bell CC, House C, Dawson SJ, Hawkins ED, Drewes G, Prinjha RK, Rodriguez R, Grandi P, Dawson MA. Tyler DS, et al. Science. 2017 Jun 30;356(6345):1397-1401. doi: 10.1126/science.aal2066. Epub 2017 Jun 15. Science. 2017. PMID: 28619718 Free PMC article.
Quinolizinium as a new fluorescent lysosomotropic probe.
Zacharioudakis E, Cañeque T, Custodio R, Müller S, Cuadro AM, Vaquero JJ, Rodriguez R. Zacharioudakis E, et al. Bioorg Med Chem Lett. 2017 Jan 15;27(2):203-207. doi: 10.1016/j.bmcl.2016.11.074. Epub 2016 Nov 24. Bioorg Med Chem Lett. 2017. PMID: 27919658