[Research progress in non-coding RNAs in mediating immune responses of macrophages to Mycobacterium tuberculosis infection]

Tuberculosis (TB) is a chronic infectious disease caused by mycobacterium tuberculosis (MTB) infection. Macrophages are the first line in defensing MTB infection and the main host cells for the growth and persistence of MTB. Changes in macrophage function are critical for the host response to tuberculosis. Non-coding RNAs are involved in the pathophysiological process of many diseases, including TB, and play a very important regulatory role in the macrophage mediated immune response process. Therefore, we reviewed the mechanisms of the non-coding RNAs mediated function alteration of macrophages, in order to facilitate identification of potential therapeutic targets for host-directed anti-TB treatment.