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7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a benzodiazepine, suppresses keratinocyte proliferation and has antipsoriatic activity in the human skin-severe, combined immunodeficient mouse transplant model.
Bhagavathula N, Nerusu KC, Hanosh A, Aslam MN, Sundberg TB, Opipari AW Jr, Johnson K, Kang S, Glick GD, Varani J. Bhagavathula N, et al. J Pharmacol Exp Ther. 2008 Mar;324(3):938-47. doi: 10.1124/jpet.107.130955. Epub 2007 Nov 30. J Pharmacol Exp Ther. 2008. PMID: 18055879