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Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule.
Grinkevich VV, Vema A, Fawkner K, Issaeva N, Andreotti V, Dickinson ER, Hedström E, Spinnler C, Inga A, Larsson LG, Karlén A, Wilhelm M, Barran PE, Okorokov AL, Selivanova G, Zawacka-Pankau JE. Grinkevich VV, et al. Front Mol Biosci. 2022 Jun 1;9:823195. doi: 10.3389/fmolb.2022.823195. eCollection 2022. Front Mol Biosci. 2022. PMID: 35720128 Free PMC article.
Discovery of Novel Isatin-Based p53 Inducers.
Davidovich P, Aksenova V, Petrova V, Tentler D, Orlova D, Smirnov S, Gurzhiy V, Okorokov AL, Garabadzhiu A, Melino G, Barlev N, Tribulovich V. Davidovich P, et al. ACS Med Chem Lett. 2015 Jul 6;6(8):856-60. doi: 10.1021/acsmedchemlett.5b00011. eCollection 2015 Aug 13. ACS Med Chem Lett. 2015. PMID: 26288684 Free PMC article.
Two p53 tetramers bind one consensus DNA response element.
Kearns S, Lurz R, Orlova EV, Okorokov AL. Kearns S, et al. Nucleic Acids Res. 2016 Jul 27;44(13):6185-99. doi: 10.1093/nar/gkw215. Epub 2016 Mar 31. Nucleic Acids Res. 2016. PMID: 27034469 Free PMC article.
A novel p53-Cdc7 link induced by genotoxic stress.
Masai H. Masai H. Cell Cycle. 2017 Apr 18;16(8):735-736. doi: 10.1080/15384101.2017.1304746. Epub 2017 Mar 15. Cell Cycle. 2017. PMID: 28296554 Free PMC article. No abstract available.