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Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyrene.
Hu X, O'Donnell R, Srivastava SK, Xia H, Zimniak P, Nanduri B, Bleicher RJ, Awasthi S, Awasthi YC, Ji X, Singh SV. Hu X, et al. Biochem Biophys Res Commun. 1997 Jun 18;235(2):424-8. doi: 10.1006/bbrc.1997.6777. Biochem Biophys Res Commun. 1997. PMID: 9199210