CA132529/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

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SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK).

Laderoute KR, Calaoagan JM, Madrid PB, Klon AE, Ehrlich PJ. Laderoute KR, et al. Cancer Biol Ther. 2010 Jul 1;10(1):68-76. doi: 10.4161/cbt.10.1.12162. Epub 2010 Jul 26. Cancer Biol Ther. 2010. PMID: 20495370 Free PMC article.

The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity.

Machrouhi F, Ouhamou N, Laderoute K, Calaoagan J, Bukhtiyarova M, Ehrlich PJ, Klon AE. Machrouhi F, et al. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. doi: 10.1016/j.bmcl.2010.09.088. Epub 2010 Sep 19. Bioorg Med Chem Lett. 2010. PMID: 20932747 Free PMC article.

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