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Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.
Nashmi R, Xiao C, Deshpande P, McKinney S, Grady SR, Whiteaker P, Huang Q, McClure-Begley T, Lindstrom JM, Labarca C, Collins AC, Marks MJ, Lester HA. Nashmi R, et al. J Neurosci. 2007 Aug 1;27(31):8202-18. doi: 10.1523/JNEUROSCI.2199-07.2007. J Neurosci. 2007. PMID: 17670967 Free PMC article.