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Development of κ opioid receptor antagonists.
Carroll FI, Carlezon WA Jr. Carroll FI, et al. J Med Chem. 2013 Mar 28;56(6):2178-95. doi: 10.1021/jm301783x. Epub 2013 Feb 14. J Med Chem. 2013. PMID: 23360448 Free PMC article. Review.
Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile.
Kormos CM, Gichinga MG, Maitra R, Runyon SP, Thomas JB, Brieaddy LE, Mascarella SW, Navarro HA, Carroll FI. Kormos CM, et al. J Med Chem. 2014 Sep 11;57(17):7367-81. doi: 10.1021/jm5008177. Epub 2014 Aug 25. J Med Chem. 2014. PMID: 25133923 Free PMC article.
Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement in rats.
Beardsley PM, Pollard GT, Howard JL, Carroll FI. Beardsley PM, et al. Psychopharmacology (Berl). 2010 Jun;210(2):189-98. doi: 10.1007/s00213-010-1846-3. Epub 2010 Apr 7. Psychopharmacology (Berl). 2010. PMID: 20372878 Free PMC article.