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Page 1
Single-cell brain organoid screening identifies developmental defects in autism.
Li C, Fleck JS, Martins-Costa C, Burkard TR, Themann J, Stuempflen M, Peer AM, Vertesy Á, Littleboy JB, Esk C, Elling U, Kasprian G, Corsini NS, Treutlein B, Knoblich JA. Li C, et al. Nature. 2023 Sep;621(7978):373-380. doi: 10.1038/s41586-023-06473-y. Epub 2023 Sep 13. Nature. 2023. PMID: 37704762 Free PMC article.
Genetic engineering in organoids.
Teriyapirom I, Batista-Rocha AS, Koo BK. Teriyapirom I, et al. J Mol Med (Berl). 2021 Apr;99(4):555-568. doi: 10.1007/s00109-020-02029-z. Epub 2021 Jan 18. J Mol Med (Berl). 2021. PMID: 33459801 Free PMC article. Review.
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum.
Martins-Costa C, Wiegers A, Pham VA, Sidhaye J, Doleschall B, Novatchkova M, Lendl T, Piber M, Peer A, Möseneder P, Stuempflen M, Chow SYA, Seidl R, Prayer D, Höftberger R, Kasprian G, Ikeuchi Y, Corsini NS, Knoblich JA. Martins-Costa C, et al. Cell Stem Cell. 2024 Jun 6;31(6):866-885.e14. doi: 10.1016/j.stem.2024.04.014. Epub 2024 May 7. Cell Stem Cell. 2024. PMID: 38718796 Free article.
Cerebral organoids display dynamic clonal growth and tunable tissue replenishment.
Lindenhofer D, Haendeler S, Esk C, Littleboy JB, Brunet Avalos C, Naas J, Pflug FG, van de Ven EGP, Reumann D, Baffet AD, von Haeseler A, Knoblich JA. Lindenhofer D, et al. Nat Cell Biol. 2024 May;26(5):710-718. doi: 10.1038/s41556-024-01412-z. Epub 2024 May 7. Nat Cell Biol. 2024. PMID: 38714853 Free PMC article.
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.
Huth M, Santini L, Galimberti E, Ramesmayer J, Titz-Teixeira F, Sehlke R, Oberhuemer M, Stummer S, Herzog V, Garmhausen M, Romeike M, Chugunova A, Leesch F, Holcik L, Weipoltshammer K, Lackner A, Schoefer C, von Haeseler A, Buecker C, Pauli A, Ameres SL, Smith A, Beyer A, Leeb M. Huth M, et al. Genes Dev. 2022 Mar 1;36(5-6):348-367. doi: 10.1101/gad.347690.120. Epub 2022 Mar 3. Genes Dev. 2022. PMID: 35241478 Free PMC article.