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l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.
Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S. Kundu A, et al. J Clin Invest. 2024 May 14;134(13):e171294. doi: 10.1172/JCI171294. J Clin Invest. 2024. PMID: 38743486 Free PMC article.
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.
Brinkley G, Nam H, Shim E, Kirkman R, Kundu A, Karki S, Heidarian Y, Tennessen JM, Liu J, Locasale JW, Guo T, Wei S, Gordetsky J, Johnson-Pais TL, Absher D, Rakheja D, Challa AK, Sudarshan S. Brinkley G, et al. Dis Model Mech. 2020 Nov 27;13(11):dmm045898. doi: 10.1242/dmm.045898. Dis Model Mech. 2020. PMID: 32928875 Free PMC article.
The oncometabolite L-2-hydroxyglutarate is a common product of dipteran larval development.
Mahmoudzadeh NH, Fitt AJ, Schwab DB, Martenis WE, Nease LM, Owings CG, Brinkley GJ, Li H, Karty JA, Sudarshan S, Hardy RW, Moczek AP, Picard CJ, Tennessen JM. Mahmoudzadeh NH, et al. Insect Biochem Mol Biol. 2020 Dec;127:103493. doi: 10.1016/j.ibmb.2020.103493. Epub 2020 Nov 3. Insect Biochem Mol Biol. 2020. PMID: 33157229 Free PMC article.