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Page 1
Molecular basis of proton-sensing by G protein-coupled receptors.
Howard MK, Hoppe N, Huang XP, Macdonald CB, Mehrota E, Grimes PR, Zahm A, Trinidad DD, English J, Coyote-Maestas W, Manglik A. Howard MK, et al. bioRxiv [Preprint]. 2024 Apr 18:2024.04.17.590000. doi: 10.1101/2024.04.17.590000. bioRxiv. 2024. PMID: 38659943 Free PMC article. Preprint.
The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. Yee SW, et al. bioRxiv [Preprint]. 2023 Jun 7:2023.06.06.543963. doi: 10.1101/2023.06.06.543963. bioRxiv. 2023. Update in: Mol Cell. 2024 May 16;84(10):1932-1947.e10. doi: 10.1016/j.molcel.2024.04.008. PMID: 37333090 Free PMC article. Updated. Preprint.
Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS. Estevam GO, et al. bioRxiv [Preprint]. 2024 May 6:2023.08.03.551866. doi: 10.1101/2023.08.03.551866. bioRxiv. 2024. Update in: Elife. 2024 Sep 13;12:RP91619. doi: 10.7554/eLife.91619. PMID: 37577651 Free PMC article. Updated. Preprint.