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Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization.
Buczynski G, Grove B, Nomura A, Kleve M, Bush J, Firtel RA, Cardelli J. Buczynski G, et al. J Cell Biol. 1997 Mar 24;136(6):1271-86. doi: 10.1083/jcb.136.6.1271. J Cell Biol. 1997. PMID: 9087443 Free PMC article.