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The let-7 microRNA represses cell proliferation pathways in human cells.
Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D, Slack FJ. Johnson CD, et al. Cancer Res. 2007 Aug 15;67(16):7713-22. doi: 10.1158/0008-5472.CAN-07-1083. Cancer Res. 2007. PMID: 17699775
The let-7 microRNA reduces tumor growth in mouse models of lung cancer.
Esquela-Kerscher A, Trang P, Wiggins JF, Patrawala L, Cheng A, Ford L, Weidhaas JB, Brown D, Bader AG, Slack FJ. Esquela-Kerscher A, et al. Cell Cycle. 2008 Mar 15;7(6):759-64. doi: 10.4161/cc.7.6.5834. Epub 2008 Mar 3. Cell Cycle. 2008. PMID: 18344688