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Proton export upregulates aerobic glycolysis.
Russell S, Xu L, Kam Y, Abrahams D, Ordway B, Lopez AS, Bui MM, Johnson J, Epstein T, Ruiz E, Lloyd MC, Swietach P, Verduzco D, Wojtkowiak J, Gillies RJ. Russell S, et al. BMC Biol. 2022 Jul 15;20(1):163. doi: 10.1186/s12915-022-01340-0. BMC Biol. 2022. PMID: 35840963 Free PMC article.
T-cells produce acidic niches in lymph nodes to suppress their own effector functions.
Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ. Wu H, et al. Nat Commun. 2020 Aug 17;11(1):4113. doi: 10.1038/s41467-020-17756-7. Nat Commun. 2020. PMID: 32807791 Free PMC article.