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A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.
Alphonse N, Wanford JJ, Voak AA, Gay J, Venkhaya S, Burroughs O, Mathew S, Lee T, Evans SL, Zhao W, Frowde K, Alrehaili A, Dickenson RE, Munk M, Panina S, Mahmood IF, Llorian M, Stanifer ML, Boulant S, Berchtold MW, Bergeron JRC, Wack A, Lesser CF, Odendall C. Alphonse N, et al. Cell. 2022 Jun 23;185(13):2354-2369.e17. doi: 10.1016/j.cell.2022.04.028. Epub 2022 May 13. Cell. 2022. PMID: 35568036 Free PMC article.
Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses.
Schnepf D, Crotta S, Thamamongood T, Stanifer M, Polcik L, Ohnemus A, Vier J, Jakob C, Llorian M, Gad HH, Hartmann R, Strobl B, Kirschnek S, Boulant S, Schwemmle M, Wack A, Staeheli P. Schnepf D, et al. Sci Immunol. 2021 May 14;6(59):eabd5318. doi: 10.1126/sciimmunol.abd5318. Sci Immunol. 2021. PMID: 33990378 Free PMC article.
The interferon landscape along the respiratory tract impacts the severity of COVID-19.
Sposito B, Broggi A, Pandolfi L, Crotta S, Clementi N, Ferrarese R, Sisti S, Criscuolo E, Spreafico R, Long JM, Ambrosi A, Liu E, Frangipane V, Saracino L, Bozzini S, Marongiu L, Facchini FA, Bottazzi A, Fossali T, Colombo R, Clementi M, Tagliabue E, Chou J, Pontiroli AE, Meloni F, Wack A, Mancini N, Zanoni I. Sposito B, et al. Cell. 2021 Sep 16;184(19):4953-4968.e16. doi: 10.1016/j.cell.2021.08.016. Epub 2021 Aug 19. Cell. 2021. PMID: 34492226 Free PMC article.
Impaired immune response drives age-dependent severity of COVID-19.
Beer J, Crotta S, Breithaupt A, Ohnemus A, Becker J, Sachs B, Kern L, Llorian M, Ebert N, Labroussaa F, Nhu Thao TT, Trueeb BS, Jores J, Thiel V, Beer M, Fuchs J, Kochs G, Wack A, Schwemmle M, Schnepf D. Beer J, et al. J Exp Med. 2022 Dec 5;219(12):e20220621. doi: 10.1084/jem.20220621. Epub 2022 Sep 21. J Exp Med. 2022. PMID: 36129445 Free PMC article.
13 results