G1000277/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2013	3
2014	5
2015	2
2016	2
2018	1
2024	0

1

The molecular and cellular pathology of α₁-antitrypsin deficiency.

Gooptu B, Dickens JA, Lomas DA. Gooptu B, et al. Trends Mol Med. 2014 Feb;20(2):116-27. doi: 10.1016/j.molmed.2013.10.007. Epub 2013 Dec 25. Trends Mol Med. 2014. PMID: 24374162 Review.

2

New Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms.

Marciniak SJ, Ordóñez A, Dickens JA, Chambers JE, Patel V, Dominicus CS, Malzer E. Marciniak SJ, et al. Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S289-96. doi: 10.1513/AnnalsATS.201506-358KV. Ann Am Thorac Soc. 2016. PMID: 27564663 Review.

3

Circulating polymers in α1-antitrypsin deficiency.

Tan L, Dickens JA, Demeo DL, Miranda E, Perez J, Rashid ST, Day J, Ordoñez A, Marciniak SJ, Haq I, Barker AF, Campbell EJ, Eden E, McElvaney NG, Rennard SI, Sandhaus RA, Stocks JM, Stoller JK, Strange C, Turino G, Rouhani FN, Brantly M, Lomas DA. Tan L, et al. Eur Respir J. 2014 May;43(5):1501-4. doi: 10.1183/09031936.00111213. Epub 2014 Mar 6. Eur Respir J. 2014. PMID: 24603821 Free article. No abstract available.

4

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.

Tan L, Perez J, Mela M, Miranda E, Burling KA, Rouhani FN, DeMeo DL, Haq I, Irving JA, Ordóñez A, Dickens JA, Brantly M, Marciniak SJ, Alexander GJ, Gooptu B, Lomas DA. Tan L, et al. Int J Biochem Cell Biol. 2015 Jan;58:81-91. doi: 10.1016/j.biocel.2014.11.005. Epub 2014 Nov 13. Int J Biochem Cell Biol. 2015. PMID: 25462157 Free PMC article.

5

Measuring the effects of α₁ -antitrypsin polymerisation on the structure and biophysical properties of the endoplasmic reticulum.

Chambers JE, Dickens JA, Marciniak SJ. Chambers JE, et al. Biol Cell. 2018 Nov;110(11):249-255. doi: 10.1111/boc.201800023. Epub 2018 Sep 10. Biol Cell. 2018. PMID: 30129166 Review.

6

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization.

Irving JA, Haq I, Dickens JA, Faull SV, Lomas DA. Irving JA, et al. Biochem J. 2014 May 15;460(1):103-15. doi: 10.1042/BJ20131650. Biochem J. 2014. PMID: 24552432 Free PMC article.

7

Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin.

van 't Wout EF, Dickens JA, van Schadewijk A, Haq I, Kwok HF, Ordóñez A, Murphy G, Stolk J, Lomas DA, Hiemstra PS, Marciniak SJ. van 't Wout EF, et al. Hum Mol Genet. 2014 Feb 15;23(4):929-41. doi: 10.1093/hmg/ddt487. Epub 2013 Oct 4. Hum Mol Genet. 2014. PMID: 24097797 Free PMC article.

8

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.

Haq I, Irving JA, Faull SV, Dickens JA, Ordóñez A, Belorgey D, Gooptu B, Lomas DA. Haq I, et al. Biosci Rep. 2013 Jun 25;33(3):e00046. doi: 10.1042/BSR20130038. Biosci Rep. 2013. PMID: 23659468 Free PMC article.

9

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.

Ordóñez A, Pérez J, Tan L, Dickens JA, Motamedi-Shad N, Irving JA, Haq I, Ekeowa U, Marciniak SJ, Miranda E, Lomas DA. Ordóñez A, et al. FASEB J. 2015 Jun;29(6):2667-78. doi: 10.1096/fj.14-267351. Epub 2015 Mar 10. FASEB J. 2015. PMID: 25757566 Free PMC article.

10

The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.

Dickens JA, Ordóñez A, Chambers JE, Beckett AJ, Patel V, Malzer E, Dominicus CS, Bradley J, Peden AA, Prior IA, Lomas DA, Marciniak SJ. Dickens JA, et al. FASEB J. 2016 Dec;30(12):4083-4097. doi: 10.1096/fj.201600430R. Epub 2016 Sep 6. FASEB J. 2016. PMID: 27601439 Free PMC article.

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