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Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.
Ray NR, Kunkle BW, Hamilton-Nelson K, Kurup JT, Rajabli F, Qiao M, Vardarajan BN, Cosacak MI, Kizil C, Jean-Francois M, Cuccaro M, Reyes-Dumeyer D, Cantwell L, Kuzma A, Vance JM, Gao S, Hendrie HC, Baiyewu O, Ogunniyi A, Akinyemi RO; Alzheimer's Disease Genetics Consortium; Lee WP, Martin ER, Wang LS, Beecham GW, Bush WS, Xu W, Jin F, Wang L, Farrer LA, Haines JL, Byrd GS, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C. Ray NR, et al. Alzheimers Dement. 2024 Aug;20(8):5247-5261. doi: 10.1002/alz.13880. Epub 2024 Jul 3. Alzheimers Dement. 2024. PMID: 38958117 Free PMC article.
INTRODUCTION: Despite a two-fold risk, individuals of African ancestry have been underrepresented in Alzheimer's disease (AD) genomics efforts. METHODS: Genome-wide association studies (GWAS) of 2,903 AD cases and 6,265 controls of African ancestry. ...Single varian …
INTRODUCTION: Despite a two-fold risk, individuals of African ancestry have been underrepresented in Alzheimer's disease (AD) genomics …
Epigenetic variation in OPRM1 gene in opioid-exposed mother-infant dyads.
Wachman EM, Hayes MJ, Shrestha H, Nikita FNU, Nolin A, Hoyo L, Daigle K, Jones HE, Nielsen DA. Wachman EM, et al. Genes Brain Behav. 2018 Sep;17(7):e12476. doi: 10.1111/gbb.12476. Epub 2018 Apr 19. Genes Brain Behav. 2018. PMID: 29575474 Free article.
Infants were monitored for NAS and treated with replacement opioids according to institutional protocol. The association between DNA methylation level at each CpG site with NAS outcome measures was evaluated using linear and logistic regression models. ...
Infants were monitored for NAS and treated with replacement opioids according to institutional protocol. The association between DNA …