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TAK1 is an essential regulator of BMP signalling in cartilage.
Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. Shim JH, et al. EMBO J. 2009 Jul 22;28(14):2028-41. doi: 10.1038/emboj.2009.162. Epub 2009 Jun 18. EMBO J. 2009. PMID: 19536134 Free PMC article.
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.
Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. Greenblatt MB, et al. J Clin Invest. 2010 Jul;120(7):2457-73. doi: 10.1172/JCI42285. Epub 2010 Jun 14. J Clin Invest. 2010. PMID: 20551513 Free PMC article.