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Modeling ALS and FTD with iPSC-derived neurons.
Lee S, Huang EJ. Lee S, et al. Brain Res. 2017 Feb 1;1656:88-97. doi: 10.1016/j.brainres.2015.10.003. Epub 2015 Oct 14. Brain Res. 2017. PMID: 26462653 Free PMC article. Review.
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
Sephton CF, Tang AA, Kulkarni A, West J, Brooks M, Stubblefield JJ, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz J, Yu G. Sephton CF, et al. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4769-78. doi: 10.1073/pnas.1406162111. Epub 2014 Oct 16. Proc Natl Acad Sci U S A. 2014. PMID: 25324524 Free PMC article.
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ. Qiu H, et al. J Clin Invest. 2014 Mar;124(3):981-99. doi: 10.1172/JCI72723. Epub 2014 Feb 10. J Clin Invest. 2014. PMID: 24509083 Free PMC article.