TH2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells

J Allergy Clin Immunol. 2009 Sep;124(3):612-4, 614.e1-2. doi: 10.1016/j.jaci.2009.04.039. Epub 2009 Jul 9.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Appetite / genetics*
  • Appetite / immunology
  • Asthma / etiology
  • Asthma / genetics*
  • Chromosomes, Human, Pair 12 / genetics
  • Cytokines / immunology*
  • Cytokines / pharmacology
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / immunology*
  • Gene Expression Profiling
  • Gene Silencing
  • Humans
  • Hypothalamic Hormones / genetics*
  • Interleukin-4 / immunology
  • Interleukin-4 / pharmacology
  • Melanins / genetics*
  • Mice
  • Obesity / complications*
  • Pituitary Hormones / genetics*
  • RNA, Small Interfering / metabolism
  • STAT6 Transcription Factor / genetics
  • STAT6 Transcription Factor / metabolism
  • Th2 Cells / drug effects
  • Th2 Cells / immunology*
  • Tumor Necrosis Factor-alpha / immunology
  • Tumor Necrosis Factor-alpha / pharmacology

Substances

  • Cytokines
  • Hypothalamic Hormones
  • IL4 protein, human
  • Melanins
  • Pituitary Hormones
  • RNA, Small Interfering
  • STAT6 Transcription Factor
  • STAT6 protein, human
  • Tumor Necrosis Factor-alpha
  • Interleukin-4
  • melanin-concentrating hormone