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Page 1
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT. Sykes DB, et al. Cell. 2016 Sep 22;167(1):171-186.e15. doi: 10.1016/j.cell.2016.08.057. Epub 2016 Sep 15. Cell. 2016. PMID: 27641501 Free PMC article.
Modulating Cell Fate as a Therapeutic Strategy.
Lin B, Srikanth P, Castle AC, Nigwekar S, Malhotra R, Galloway JL, Sykes DB, Rajagopal J. Lin B, et al. Cell Stem Cell. 2018 Sep 6;23(3):329-341. doi: 10.1016/j.stem.2018.05.009. Epub 2018 Jun 14. Cell Stem Cell. 2018. PMID: 29910150 Free PMC article. Review.
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.
van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. van Gastel N, et al. Cell Metab. 2020 Sep 1;32(3):391-403.e6. doi: 10.1016/j.cmet.2020.07.009. Epub 2020 Aug 6. Cell Metab. 2020. PMID: 32763164 Free PMC article.
TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils.
Viens AL, Timmer KD, Alexander NJ, Barghout R, Milosevic J, Hopke A, Atallah NJ, Scherer AK, Sykes DB, Irimia D, Mansour MK. Viens AL, et al. J Immunol. 2022 Apr 1;208(7):1664-1674. doi: 10.4049/jimmunol.2100599. Epub 2022 Mar 11. J Immunol. 2022. PMID: 35277418 Free PMC article.
Biguanides enhance antifungal activity against Candida glabrata.
Xu S, Feliu M, Lord AK, Lukason DP, Negoro PE, Khan NS, Dagher Z, Feldman MB, Reedy JL, Steiger SN, Tam JM, Soukas AA, Sykes DB, Mansour MK. Xu S, et al. Virulence. 2018;9(1):1150-1162. doi: 10.1080/21505594.2018.1475798. Virulence. 2018. PMID: 29962263 Free PMC article.
Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species.
Negoro PE, Xu S, Dagher Z, Hopke A, Reedy JL, Feldman MB, Khan NS, Viens AL, Alexander NJ, Atallah NJ, Scherer AK, Dutko RA, Jeffery J, Kernien JF, Fites JS, Nett JE, Klein BS, Vyas JM, Irimia D, Sykes DB, Mansour MK. Negoro PE, et al. mBio. 2020 May 12;11(3):e02043-19. doi: 10.1128/mBio.02043-19. mBio. 2020. PMID: 32398316 Free PMC article.
Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.
Zee BM, Poels KE, Yao CH, Kawabata KC, Wu G, Duy C, Jacobus WD, Senior E, Endress JE, Jambhekar A, Lovitch SB, Ma J, Dhall A, Harris IS, Blanco MA, Sykes DB, Licht JD, Weinstock DM, Melnick A, Haigis MC, Michor F, Shi Y. Zee BM, et al. iScience. 2021 May 25;24(6):102651. doi: 10.1016/j.isci.2021.102651. eCollection 2021 Jun 25. iScience. 2021. PMID: 34151238 Free PMC article.
11 results