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HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E.
Cosper PF, Hrycyniak LCF, Paracha M, Lee DL, Wan J, Jones K, Bice SA, Nickel K, Mallick S, Taylor AM, Kimple RJ, Lambert PF, Weaver BA. Cosper PF, et al. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2216700120. doi: 10.1073/pnas.2216700120. Epub 2023 Mar 29. Proc Natl Acad Sci U S A. 2023. PMID: 36989302 Free PMC article.
Chromosomal instability increases radiation sensitivity.
Cosper PF, Paracha M, Jones KM, Hrycyniak L, Henderson L, Bryan A, Eyzaguirre D, McCunn E, Boulanger E, Wan J, Nickel KP, Horner V, Hu R, Harari PM, Kimple RJ, Weaver BA. Cosper PF, et al. bioRxiv [Preprint]. 2024 Sep 19:2024.09.13.612942. doi: 10.1101/2024.09.13.612942. bioRxiv. 2024. PMID: 39345631 Free PMC article. Preprint.