MR/R001413/1/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2017	1
2019	1
2020	5
2021	3
2022	3
2025	0

1

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

Śledzińska A, Vila de Mucha M, Bergerhoff K, Hotblack A, Demane DF, Ghorani E, Akarca AU, Marzolini MAV, Solomon I, Vargas FA, Pule M, Ono M, Seddon B, Kassiotis G, Ariyan CE, Korn T, Marafioti T, Lord GM, Stauss H, Jenner RG, Peggs KS, Quezada SA. Śledzińska A, et al. Immunity. 2020 Jan 14;52(1):151-166.e6. doi: 10.1016/j.immuni.2019.12.007. Epub 2020 Jan 7. Immunity. 2020. PMID: 31924474 Free PMC article.

2

Regulatory T-cell therapy in Crohn's disease: challenges and advances.

Clough JN, Omer OS, Tasker S, Lord GM, Irving PM. Clough JN, et al. Gut. 2020 May;69(5):942-952. doi: 10.1136/gutjnl-2019-319850. Epub 2020 Jan 24. Gut. 2020. PMID: 31980447 Free PMC article. Review.

3

Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease.

Omer OS, Hertweck A, Roberts LB, Lo JW, Clough JN, Jackson I, Pantazi ED, Irving PM, MacDonald TT, Pavlidis P, Jenner RG, Lord GM. Omer OS, et al. Cell Mol Gastroenterol Hepatol. 2022;14(3):625-641. doi: 10.1016/j.jcmgh.2022.05.011. Epub 2022 Jun 1. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35660024 Free PMC article.

4

A population of naive-like CD4⁺ T cells stably polarized to the T_H 1 lineage.

Lo JW, de Mucha MV, Henderson S, Roberts LB, Constable LE, Garrido-Mesa N, Hertweck A, Stolarczyk E, Houlder EL, Jackson I, MacDonald AS, Powell N, Neves JF, Howard JK, Jenner RG, Lord GM. Lo JW, et al. Eur J Immunol. 2022 Apr;52(4):566-581. doi: 10.1002/eji.202149228. Epub 2022 Feb 12. Eur J Immunol. 2022. PMID: 35092032 Free PMC article.

5

The Study of Protein-DNA Interactions in CD4⁺ T-Cells Using ChIPmentation.

Hertweck A, Jenner RG. Hertweck A, et al. Methods Mol Biol. 2021;2285:201-216. doi: 10.1007/978-1-0716-1311-5_17. Methods Mol Biol. 2021. PMID: 33928555

6

Exhausted CD4⁺ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression.

Villegas-Mendez A, Khandelwal G, McGowan LM, Dookie RS, Haley MJ, George C, Sims D, Lord GM, Sinclair LV, Jenner RG, Couper KN. Villegas-Mendez A, et al. J Immunol. 2020 Sep 15;205(6):1608-1619. doi: 10.4049/jimmunol.2000450. Epub 2020 Aug 17. J Immunol. 2020. PMID: 32817333 Free PMC article.

7

The Th1 cell regulatory circuitry is largely conserved between human and mouse.

Henderson S, Pullabhatla V, Hertweck A, de Rinaldis E, Herrero J, Lord GM, Jenner RG. Henderson S, et al. Life Sci Alliance. 2021 Sep 16;4(11):e202101075. doi: 10.26508/lsa.202101075. Print 2021 Nov. Life Sci Alliance. 2021. PMID: 34531288 Free PMC article.

8

Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death.

Cottone L, Cribbs AP, Khandelwal G, Wells G, Ligammari L, Philpott M, Tumber A, Lombard P, Hookway ES, Szommer T, Johansson C, Brennan PE, Pillay N, Jenner RG, Oppermann U, Flanagan AM. Cottone L, et al. Cancer Res. 2020 Oct 15;80(20):4540-4551. doi: 10.1158/0008-5472.CAN-20-1387. Epub 2020 Aug 27. Cancer Res. 2020. PMID: 32855205 Free PMC article.

9

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

Soderquest K, Hertweck A, Giambartolomei C, Henderson S, Mohamed R, Goldberg R, Perucha E, Franke L, Herrero J, Plagnol V, Jenner RG, Lord GM. Soderquest K, et al. PLoS Genet. 2017 Feb 10;13(2):e1006587. doi: 10.1371/journal.pgen.1006587. eCollection 2017 Feb. PLoS Genet. 2017. PMID: 28187197 Free PMC article.

10

microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.

Anandagoda N, Willis JC, Hertweck A, Roberts LB, Jackson I, Gökmen MR, Jenner RG, Howard JK, Lord GM. Anandagoda N, et al. J Clin Invest. 2019 Mar 1;129(3):1257-1271. doi: 10.1172/JCI124725. Epub 2019 Feb 11. J Clin Invest. 2019. PMID: 30741720 Free PMC article.

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