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The genetics of obesity: from discovery to biology.
Loos RJF, Yeo GSH. Loos RJF, et al. Nat Rev Genet. 2022 Feb;23(2):120-133. doi: 10.1038/s41576-021-00414-z. Epub 2021 Sep 23. Nat Rev Genet. 2022. PMID: 34556834 Free PMC article. Review.
Systemic proteome adaptions to 7-day complete caloric restriction in humans.
Pietzner M, Uluvar B, Kolnes KJ, Jeppesen PB, Frivold SV, Skattebo Ø, Johansen EI, Skålhegg BS, Wojtaszewski JFP, Kolnes AJ, Yeo GSH, O'Rahilly S, Jensen J, Langenberg C. Pietzner M, et al. Nat Metab. 2024 Apr;6(4):764-777. doi: 10.1038/s42255-024-01008-9. Epub 2024 Mar 1. Nat Metab. 2024. PMID: 38429390
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy.
Yeo GSH, Chao DHM, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE, Larson CM, Luquet S, Clarke I, Sharma S, Clément K, Cowley MA, Haskell-Luevano C, Van Der Ploeg L, Adan RAH. Yeo GSH, et al. Mol Metab. 2021 Jun;48:101206. doi: 10.1016/j.molmet.2021.101206. Epub 2021 Mar 6. Mol Metab. 2021. PMID: 33684608 Free PMC article. Review.
Human embryonic genome activation initiates at the one-cell stage.
Asami M, Lam BYH, Ma MK, Rainbow K, Braun S, VerMilyea MD, Yeo GSH, Perry ACF. Asami M, et al. Cell Stem Cell. 2022 Feb 3;29(2):209-216.e4. doi: 10.1016/j.stem.2021.11.012. Epub 2021 Dec 21. Cell Stem Cell. 2022. PMID: 34936886 Free PMC article.
The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth.
Sandovici I, Georgopoulou A, Pérez-García V, Hufnagel A, López-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constância M. Sandovici I, et al. Dev Cell. 2022 Jan 10;57(1):63-79.e8. doi: 10.1016/j.devcel.2021.12.005. Epub 2021 Dec 27. Dev Cell. 2022. PMID: 34963058 Free PMC article.
Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.
Wagner S, Brierley DI, Leeson-Payne A, Jiang W, Chianese R, Lam BYH, Dowsett GKC, Cristiano C, Lyons D, Reimann F, Gribble FM, Martinez de Morentin PB, Yeo GSH, Trapp S, Heisler LK. Wagner S, et al. Mol Metab. 2023 Feb;68:101665. doi: 10.1016/j.molmet.2022.101665. Epub 2022 Dec 30. Mol Metab. 2023. PMID: 36592795 Free PMC article.
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease.
Zhao Y, Chukanova M, Kentistou KA, Fairhurst-Hunter Z, Siegert AM, Jia RY, Dowsett GKC, Gardner EJ, Lawler K, Day FR, Kaisinger LR, Tung YL, Lam BYH, Chen HC, Wang Q, Berumen-Campos J, Kuri-Morales P, Tapia-Conyer R, Alegre-Diaz J, Barroso I, Emberson J, Torres JM, Collins R, Saleheen D, Smith KR, Paul DS, Merkle F, Farooqi IS, Wareham NJ, Petrovski S, O'Rahilly S, Ong KK, Yeo GSH, Perry JRB. Zhao Y, et al. Nat Genet. 2024 Apr;56(4):579-584. doi: 10.1038/s41588-024-01694-x. Epub 2024 Apr 4. Nat Genet. 2024. PMID: 38575728 Free PMC article.
27 results