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HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.
Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S. Cui M, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306454120. doi: 10.1073/pnas.2306454120. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170752 Free PMC article.
STINGing organelle surface with acid.
Kuchitsu Y, Taguchi T. Kuchitsu Y, et al. EMBO Rep. 2024 Apr;25(4):1708-1710. doi: 10.1038/s44319-024-00120-x. Epub 2024 Mar 19. EMBO Rep. 2024. PMID: 38503877 Free PMC article.
A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation.
Kumagai T, Iwata A, Furuya H, Kato K, Okabe A, Toda Y, Kanai M, Fujimura L, Sakamoto A, Kageyama T, Tanaka S, Suto A, Hatano M, Kaneda A, Nakajima H. Kumagai T, et al. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2320727121. doi: 10.1073/pnas.2320727121. Epub 2024 Jun 26. Proc Natl Acad Sci U S A. 2024. PMID: 38923989 Free PMC article.
Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity.
Mukohara F, Iwata K, Ishino T, Inozume T, Nagasaki J, Ueda Y, Suzawa K, Ueno T, Ikeda H, Kawase K, Saeki Y, Kawashima S, Yamashita K, Kawahara Y, Nakamura Y, Honobe-Tabuchi A, Watanabe H, Dansako H, Kawamura T, Suzuki Y, Honda H, Mano H, Toyooka S, Kawazu M, Togashi Y. Mukohara F, et al. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2320189121. doi: 10.1073/pnas.2320189121. Epub 2024 Aug 21. Proc Natl Acad Sci U S A. 2024. PMID: 39167601