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Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.
Nussbaum DP, Martz CA, Waters AM, Barrera A, Liu A, Rutter JC, Cerda-Smith CG, Stewart AE, Wu C, Cakir M, Levandowski CB, Kantrowitz DE, McCall SJ, Pierobon M, Petricoin EF 3rd, Joshua Smith J, Reddy TE, Der CJ, Taatjes DJ, Wood KC. Nussbaum DP, et al. NPJ Precis Oncol. 2024 May 31;8(1):124. doi: 10.1038/s41698-024-00615-9. NPJ Precis Oncol. 2024. PMID: 38822082 Free PMC article.
Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience.
Boutzoukas AE, Olson R, Sellers MA, Fischer G, Hornik CD, Alibrahim O, Iheagwara K, Abulebda K, Bass AL, Irby K, Subbaswamy A, Zivick EE, Sweney J, Stormorken AG, Barker EE, Lutfi R, McCrory MC, Costello JM, Ackerman KG, Munoz Pareja JC, Dean JM, Abdelsamad N, Hanley DF Jr, Mould WA, Lane K, Stroud M, Feger BJ, Greenberg RG, Smith PB, Benjamin DK Jr, Hornik CP, Zimmerman KO, Becker ML. Boutzoukas AE, et al. Contemp Clin Trials. 2023 Feb;125:107067. doi: 10.1016/j.cct.2022.107067. Epub 2022 Dec 25. Contemp Clin Trials. 2023. PMID: 36577492 Free PMC article. Clinical Trial.
BACKGROUND: Timely trial start-up is a key determinant of trial success; however, delays during start-up are common and costly. ...METHODS: The three novel start-up mechanisms included: 1) competitive activation; 2) use of trial start …
BACKGROUND: Timely trial start-up is a key determinant of trial success; however, delays during start-up are com …
Pilot and feasibility studies in ophthalmology: fundamental keys to success.
Nanji K, Phillips M, Thabane L, Tham YC, Wong TY, Steel DH, Munk MR, Wykoff CC, Chaudhary V; Retina Evidence and Trials INternational Alliance (R.E.T.I.N.A.) Study Group. Nanji K, et al. Eye (Lond). 2025 Jan;39(1):4-6. doi: 10.1038/s41433-024-03413-6. Epub 2024 Nov 21. Eye (Lond). 2025. PMID: 39572846 No abstract available.
Safety and efficacy of hydroxychloroquine as prophylactic against COVID-19 in healthcare workers: a meta-analysis of randomised clinical trials.
Hong H, Friedland A, Hu M, Anstrom KJ, Halabi S, McKinnon JE, Amaravadi R, Rojas-Serrano J, Abella BS, Portillo-Vázquez AM, Woods CW, Hernandez AF, Boulware DR, Naggie S, Rajasingham R. Hong H, et al. BMJ Open. 2023 Jun 16;13(6):e065305. doi: 10.1136/bmjopen-2022-065305. BMJ Open. 2023. PMID: 37328184 Free PMC article.
STUDY SELECTION: Ten RCTs were identified (n=5079 participants). DATA EXTRACTION AND SYNTHESIS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used in this systematic review and meta-analysis between HCQ and placebo using a Bayesian …
STUDY SELECTION: Ten RCTs were identified (n=5079 participants). DATA EXTRACTION AND SYNTHESIS: The Preferred Reporting Items for Sys …
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.
Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin TY, Liberatore KM, Bulaon DK, Van Nest SJ, Koundouros N, Kastenhuber ER, Mercadante MN, Shobana-Ganesh K, He L, Schwartz RE, Chen S, Weinstein H, Elemento O, Piskounova E, Nilsson-Payant BE, Lee G, Trimarco JD, Burke KN, Hamele CE, Chaparian RR, Harding AT, Tata A, Zhu X, Tata PR, Smith CM, Possemato AP, Tkachev SL, Hornbeck PV, Beausoleil SA, Anand SK, Aguet F, Getz G, Davidson AD, Heesom K, Kavanagh-Williamson M, Matthews DA, tenOever BR, Cantley LC, Blenis J, Heaton NS. Yaron TM, et al. Sci Signal. 2022 Oct 25;15(757):eabm0808. doi: 10.1126/scisignal.abm0808. Epub 2022 Oct 25. Sci Signal. 2022. PMID: 36282911 Free PMC article.
Here, we used the known substrate specificities of mammalian protein kinases to deconvolute the sequence of phosphorylation events mediated by three host protein kinase families (SRPK, GSK-3, and CK1) that coordinately phosphorylate a cluster of serine and threonine residues in t …
Here, we used the known substrate specificities of mammalian protein kinases to deconvolute the sequence of phosphorylation events mediated …