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The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate.
Weisshaar N, Ma S, Ming Y, Madi A, Mieg A, Hering M, Zettl F, Mohr K, Ten Bosch N, Stichling D, Buettner M, Poschet G, Klinke G, Schulz M, Kunze-Rohrbach N, Kerber C, Klein IM, Wu J, Wang X, Cui G. Weisshaar N, et al. Nat Immunol. 2023 Nov;24(11):1921-1932. doi: 10.1038/s41590-023-01636-5. Epub 2023 Oct 9. Nat Immunol. 2023. PMID: 37813964 Free PMC article.