NS35711/NS/NINDS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2001	1
2002	1
2003	1
2005	1
2006	1
2009	1
2010	1
2025	0

1

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.

Kim YJ, Sapp E, Cuiffo BG, Sobin L, Yoder J, Kegel KB, Qin ZH, Detloff P, Aronin N, DiFiglia M. Kim YJ, et al. Neurobiol Dis. 2006 May;22(2):346-56. doi: 10.1016/j.nbd.2005.11.012. Epub 2006 Jan 19. Neurobiol Dis. 2006. PMID: 16423528

2

Huntingtin is degraded to small fragments by calpain after ischemic injury.

Kim M, Roh JK, Yoon BW, Kang L, Kim YJ, Aronin N, DiFiglia M. Kim M, et al. Exp Neurol. 2003 Sep;183(1):109-15. doi: 10.1016/s0014-4886(03)00132-8. Exp Neurol. 2003. PMID: 12957494

3

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.

Li X, Sapp E, Chase K, Comer-Tierney LA, Masso N, Alexander J, Reeves P, Kegel KB, Valencia A, Esteves M, Aronin N, Difiglia M. Li X, et al. Neurobiol Dis. 2009 Nov;36(2):374-83. doi: 10.1016/j.nbd.2009.08.003. Epub 2009 Aug 20. Neurobiol Dis. 2009. PMID: 19699304 Free PMC article.

4

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, DiFiglia M. Kim YJ, et al. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12784-9. doi: 10.1073/pnas.221451398. Proc Natl Acad Sci U S A. 2001. PMID: 11675509 Free PMC article.

5

Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.

Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M. Valencia A, et al. J Neurosci Res. 2010 Jan;88(1):179-90. doi: 10.1002/jnr.22184. J Neurosci Res. 2010. PMID: 19642201

6

Huntingtin associates with acidic phospholipids at the plasma membrane.

Kegel KB, Sapp E, Yoder J, Cuiffo B, Sobin L, Kim YJ, Qin ZH, Hayden MR, Aronin N, Scott DL, Isenberg G, Goldmann WH, DiFiglia M. Kegel KB, et al. J Biol Chem. 2005 Oct 28;280(43):36464-73. doi: 10.1074/jbc.M503672200. Epub 2005 Aug 5. J Biol Chem. 2005. PMID: 16085648 Free article.

7

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.

Chan EY, Luthi-Carter R, Strand A, Solano SM, Hanson SA, DeJohn MM, Kooperberg C, Chase KO, DiFiglia M, Young AB, Leavitt BR, Cha JH, Aronin N, Hayden MR, Olson JM. Chan EY, et al. Hum Mol Genet. 2002 Aug 15;11(17):1939-51. doi: 10.1093/hmg/11.17.1939. Hum Mol Genet. 2002. PMID: 12165556

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