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Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma Models.
Jain S, Griffith JI, Porath KA, Rathi S, Le J, Pasa TI, Decker PA, Gupta SK, Hu Z, Carlson BL, Bakken K, Burgenske DM, Feldsien TM, Lefebvre DR, Vaubel RA, Eckel-Passow JE, Reilly EB, Elmquist WF, Sarkaria JN. Jain S, et al. Clin Cancer Res. 2024 Aug 1;30(15):3287-3297. doi: 10.1158/1078-0432.CCR-24-0426. Clin Cancer Res. 2024. PMID: 38743766 Free PMC article.
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy.
Zuckermann M, He C, Andrews J, Bagchi A, Sloan-Henry R, Bianski B, Xie J, Wang Y, Twarog N, Onar-Thomas A, Ernst KJ, Yang L, Li Y, Zhu X, Ocasio JK, Budd KM, Dalton J, Li X, Chepyala D, Zhang J, Xu K, Hover L, Roach JT, Chan KC, Hofmann N, McKinnon PJ, Pfister SM, Shelat AA, Rankovic Z, Freeman BB 3rd, Chiang J, Jones DTW, Tinkle CL, Baker SJ. Zuckermann M, et al. Mol Cancer. 2024 Jun 7;23(1):123. doi: 10.1186/s12943-024-02027-6. Mol Cancer. 2024. PMID: 38849845 Free PMC article.
Genome-wide polygenic risk scores predict risk of glioma and molecular subtypes.
Nakase T, Guerra GA, Ostrom QT, Ge T, Melin BS, Wrensch M, Wiencke JK, Jenkins RB, Eckel-Passow JE; Glioma International Case-Control Study (GICC); Bondy ML, Francis SS, Kachuri L. Nakase T, et al. Neuro Oncol. 2024 Oct 3;26(10):1933-1944. doi: 10.1093/neuonc/noae112. Neuro Oncol. 2024. PMID: 38916140