P01 HL164319/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

1

A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.

Papa A, Del Rivero Morfin PJ, Chen BX, Yang L, Katchman AN, Zakharov SI, Liu G, Bohnen MS, Zheng V, Katz M, Subramaniam S, Hirsch JA, Weiss S, Dascal N, Karlin A, Pitt GS, Colecraft HM, Ben-Johny M, Marx SO. Papa A, et al. J Clin Invest. 2024 Jan 16;134(5):e176943. doi: 10.1172/JCI176943. J Clin Invest. 2024. PMID: 38227371 Free PMC article.

2

Structural insights into the regulation of RyR1 by S100A1.

Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR. Weninger G, et al. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2400497121. doi: 10.1073/pnas.2400497121. Epub 2024 Jun 25. Proc Natl Acad Sci U S A. 2024. PMID: 38917010 Free PMC article.

3

Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.

Miotto MC, Reiken S, Wronska A, Yuan Q, Dridi H, Liu Y, Weninger G, Tchagou C, Marks AR. Miotto MC, et al. Nat Commun. 2024 Sep 15;15(1):8080. doi: 10.1038/s41467-024-51791-y. Nat Commun. 2024. PMID: 39278969 Free PMC article.

4

Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies.

Morgenstern TJ, Darko-Boateng A, Afriyie E, Shanmugam SK, Zhou X, Choudhury P, Desai M, Kass RS, Clarke OB, Colecraft HM. Morgenstern TJ, et al. bioRxiv [Preprint]. 2024 May 31:2024.05.28.596281. doi: 10.1101/2024.05.28.596281. bioRxiv. 2024. PMID: 38854018 Free PMC article. Preprint.

5

Augmented Cardiac Inotropy by Phosphodiesterase Inhibition Requires Phosphorylation of Rad and Increased Calcium Current.

Katchman AN, Zakharov SI, Bohnen MS, Sanchez Jimenez A, Kushner JS, Yang L, Chen BX, Nasari A, Liu G, Rabbani DE, Han J, Leu CS, Pitt GS, Marx SO. Katchman AN, et al. Circulation. 2024 May 14;149(20):1617-1620. doi: 10.1161/CIRCULATIONAHA.123.067298. Epub 2024 May 13. Circulation. 2024. PMID: 38739694 No abstract available.

6

A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings.

Del Rivero Morfin PJ, Chavez DS, Jayaraman S, Yang L, Geisler SM, Kochiss AL, Tuluc P, Colecraft HM, Marx SO, Liu XS, Rajadhyaksha AM, Ben-Johny M. Del Rivero Morfin PJ, et al. Sci Adv. 2024 Nov;10(44):eadq3374. doi: 10.1126/sciadv.adq3374. Epub 2024 Oct 30. Sci Adv. 2024. PMID: 39475605 Free PMC article.

7

Decoding polyubiquitin regulation of K_V7. 1 functional expression with engineered linkage-selective deubiquitinases.

Shanmugam SK, Kanner SA, Zou X, Amarh E, Choudhury P, Soni R, Kass RS, Colecraft HM. Shanmugam SK, et al. bioRxiv [Preprint]. 2024 Sep 17:2024.09.17.613539. doi: 10.1101/2024.09.17.613539. bioRxiv. 2024. PMID: 39345403 Free PMC article. Preprint.

8

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene.

Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB. Kim K, et al. bioRxiv [Preprint]. 2024 Oct 24:2024.10.21.619409. doi: 10.1101/2024.10.21.619409. bioRxiv. 2024. PMID: 39484412 Free PMC article. Preprint.

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