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Using experimental evolution to probe molecular mechanisms of protein function.
Protein Sci. 2016 Feb;25(2):352-9. doi: 10.1002/pro.2836. Epub 2015 Nov 14.
Protein Sci. 2016.
PMID: 26509591
Free PMC article.
Review.
Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap.
Alawo DOA, Tahir TA, Fischer M, Bates DG, Amirova SR, Brindle NPJ.
Alawo DOA, et al.
Sci Rep. 2017 Jun 16;7(1):3658. doi: 10.1038/s41598-017-03981-6.
Sci Rep. 2017.
PMID: 28623351
Free PMC article.
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Development of an Orthogonal Tie2 Ligand Resistant to Inhibition by Ang2.
Issa E, Moss AJ, Fischer M, Kang M, Ahmed S, Farah H, Bate N, Giakomidi D, Brindle NP.
Issa E, et al.
Mol Pharm. 2018 Sep 4;15(9):3962-3968. doi: 10.1021/acs.molpharmaceut.8b00409. Epub 2018 Aug 6.
Mol Pharm. 2018.
PMID: 30036484
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