R01 AG050997/AG/NIA NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2016	3
2017	2
2018	1
2019	3
2021	2
2025	0

1

Elevated NSD3 histone methylation activity drives squamous cell lung cancer.

Yuan G, Flores NM, Hausmann S, Lofgren SM, Kharchenko V, Angulo-Ibanez M, Sengupta D, Lu X, Czaban I, Azhibek D, Vicent S, Fischle W, Jaremko M, Fang B, Wistuba II, Chua KF, Roth JA, Minna JD, Shao NY, Jaremko Ł, Mazur PK, Gozani O. Yuan G, et al. Nature. 2021 Feb;590(7846):504-508. doi: 10.1038/s41586-020-03170-y. Epub 2021 Feb 3. Nature. 2021. PMID: 33536620 Free PMC article.

2

SIRT6: Novel Mechanisms and Links to Aging and Disease.

Tasselli L, Zheng W, Chua KF. Tasselli L, et al. Trends Endocrinol Metab. 2017 Mar;28(3):168-185. doi: 10.1016/j.tem.2016.10.002. Epub 2016 Nov 9. Trends Endocrinol Metab. 2017. PMID: 27836583 Free PMC article. Review.

3

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.

You W, Rotili D, Li TM, Kambach C, Meleshin M, Schutkowski M, Chua KF, Mai A, Steegborn C. You W, et al. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011. doi: 10.1002/anie.201610082. Epub 2016 Dec 19. Angew Chem Int Ed Engl. 2017. PMID: 27990725

4

Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.

You W, Zheng W, Weiss S, Chua KF, Steegborn C. You W, et al. Sci Rep. 2019 Dec 16;9(1):19176. doi: 10.1038/s41598-019-55654-1. Sci Rep. 2019. PMID: 31844103 Free PMC article.

5

Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation.

Zheng W, Tasselli L, Li TM, Chua KF. Zheng W, et al. Genes (Basel). 2021 Sep 21;12(9):1460. doi: 10.3390/genes12091460. Genes (Basel). 2021. PMID: 34573442 Free PMC article.

6

A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.

Wang WW, Angulo-Ibanez M, Lyu J, Kurra Y, Tong Z, Wu B, Zhang L, Sharma V, Zhou J, Lin H, Gao YQ, Li W, Chua KF, Liu WR. Wang WW, et al. J Am Chem Soc. 2019 Feb 13;141(6):2462-2473. doi: 10.1021/jacs.8b12083. Epub 2019 Feb 4. J Am Chem Soc. 2019. PMID: 30653310 Free PMC article.

7

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability.

Paredes S, Angulo-Ibanez M, Tasselli L, Carlson SM, Zheng W, Li TM, Chua KF. Paredes S, et al. J Biol Chem. 2018 Jul 13;293(28):11242-11250. doi: 10.1074/jbc.AC118.003325. Epub 2018 May 4. J Biol Chem. 2018. PMID: 29728458 Free PMC article.

8

Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules.

Li TM, Coan JP, Krajewski K, Zhang L, Elias JE, Strahl BD, Gozani O, Chua KF. Li TM, et al. Sci Rep. 2019 Oct 2;9(1):14226. doi: 10.1038/s41598-019-50817-6. Sci Rep. 2019. PMID: 31578417 Free PMC article.

9

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence.

Tasselli L, Xi Y, Zheng W, Tennen RI, Odrowaz Z, Simeoni F, Li W, Chua KF. Tasselli L, et al. Nat Struct Mol Biol. 2016 May;23(5):434-40. doi: 10.1038/nsmb.3202. Epub 2016 Apr 4. Nat Struct Mol Biol. 2016. PMID: 27043296 Free PMC article.

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