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The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions.
Young JA, Becker AM, Medeiros JJ, Shapiro VS, Wang A, Farrar JD, Quill TA, Hooft van Huijsduijnen R, van Oers NS. Young JA, et al. Mol Immunol. 2008 Aug;45(14):3756-66. doi: 10.1016/j.molimm.2008.05.023. Epub 2008 Jul 9. Mol Immunol. 2008. PMID: 18614237 Free PMC article.