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Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors.
Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, Hsu D, Xu R, Harpaz N, Dannenberg AJ, Subbaramaiah K, Cooper HS, Itzkowitz SH, Abreu MT. Fukata M, et al. Gastroenterology. 2007 Dec;133(6):1869-81. doi: 10.1053/j.gastro.2007.09.008. Epub 2007 Sep 14. Gastroenterology. 2007. PMID: 18054559 Free PMC article.
Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis.
Fukata M, Shang L, Santaolalla R, Sotolongo J, Pastorini C, España C, Ungaro R, Harpaz N, Cooper HS, Elson G, Kosco-Vilbois M, Zaias J, Perez MT, Mayer L, Vamadevan AS, Lira SA, Abreu MT. Fukata M, et al. Inflamm Bowel Dis. 2011 Jul;17(7):1464-73. doi: 10.1002/ibd.21527. Epub 2010 Nov 15. Inflamm Bowel Dis. 2011. PMID: 21674704 Free PMC article.