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Single-Cell Transcriptomic Profiling of Vascular Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm.
Pedroza AJ, Tashima Y, Shad R, Cheng P, Wirka R, Churovich S, Nakamura K, Yokoyama N, Cui JZ, Iosef C, Hiesinger W, Quertermous T, Fischbein MP. Pedroza AJ, et al. Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2195-2211. doi: 10.1161/ATVBAHA.120.314670. Epub 2020 Jul 23. Arterioscler Thromb Vasc Biol. 2020. PMID: 32698686 Free PMC article.
Divergent effects of canonical and non-canonical TGF-β signalling on mixed contractile-synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms.
Pedroza AJ, Koyano T, Trojan J, Rubin A, Palmon I, Jaatinen K, Burdon G, Chang P, Tashima Y, Cui JZ, Berry G, Iosef C, Fischbein MP. Pedroza AJ, et al. J Cell Mol Med. 2020 Feb;24(3):2369-2383. doi: 10.1111/jcmm.14921. Epub 2019 Dec 30. J Cell Mol Med. 2020. PMID: 31886938 Free PMC article.
Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras-Induced ERK (Extracellular Signal-Regulated Kinase) Signaling Pathway.
Sato T, Arakawa M, Tashima Y, Tsuboi E, Burdon G, Trojan J, Koyano T, Youn YN, Penov K, Pedroza AJ, Shabazzi M, Palmon I, Nguyen MN, Connolly AJ, Yamaguchi A, Fischbein MP. Sato T, et al. J Am Heart Assoc. 2018 Nov 6;7(21):e008543. doi: 10.1161/JAHA.118.008543. J Am Heart Assoc. 2018. PMID: 30571378 Free PMC article.
Long-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model.
Okamura H, Emrich F, Trojan J, Chiu P, Dalal AR, Arakawa M, Sato T, Penov K, Koyano T, Pedroza A, Connolly AJ, Rabinovitch M, Alvira C, Fischbein MP. Okamura H, et al. Physiol Rep. 2017 Apr;5(8):e13257. doi: 10.14814/phy2.13257. Epub 2017 Apr 28. Physiol Rep. 2017. PMID: 28455451 Free PMC article.
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